Stereodivergent synthesis of 2-oxo-oligopyrrolidines by an iterative coupling strategy-Reference-Cited by-同舟云学术

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Stereodivergent synthesis of 2-oxo-oligopyrrolidines by an iterative coupling strategy

Published:2024 Issue:16 Volume:22 Page:3230-3236
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Soda Yasuki¹,Tatsumi Kumpei¹,Forner Matteo¹²^ORCID,Sato Shunsei¹,Shibuya Kana¹,Matagawa Tomoe¹,Simizu Siro¹,Chida Noritaka¹^ORCID,Okamura Toshitaka¹^ORCID,Sato Takaaki¹^ORCID

Affiliation:

1. Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan

2. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, PD, Italy

Abstract

An iterative and stereodivergent approach to synthesize 2-oxo-oligopyrrolidines was developed. The synthetic compounds exhibited antiproliferative activity according to the number of pyrrolidine rings and their stereochemical configuration.

Funder

Ministry of Education, Culture, Sports, Science and Technology

TOBE MAKI Scholarship Foundation

Kato Memorial Bioscience Foundation

Japan Science Society

Amano Institute of Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00350K

Reference45 articles.

1. Mammalian polyamine metabolism and function

2. Functions of Polyamines in Mammals

3. Polyamines and cancer: old molecules, new understanding

4. Functional polyamine metabolic enzymes and pathways encoded by the virosphere

5. Spermidine in health and disease

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