NP/MS since 1970: from the basement to the bench top

Author:

Carter Guy T.12

Affiliation:

1. Carter-Bernan Consulting

2. New City, United States

Abstract

This Highlight explores the evolution of applications of mass spectrometric technologies in the context of natural products research since the 1970's. The central themes are the analysis of mixtures, dereplication and structure determination. An example of sequential analysis of fragment ions (MS/MS) to provide detailed structural information on muraymycins is presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference32 articles.

1. F. W. McLafferty , Interpretation of Mass Spectra , Benjamin Press , 1973

2. H. Budzikiewicz , C.Djerassi , and D. H.Williams . Structure elucidation of natural products by mass spectrometry , Holden-Day , San Francisco , 1964

3. Polyene antibiotics. IV. Structure of chainin

4. Characterization of anthracycline antibiotics by desorption chemical ionization mass spectrometry

5. Recent applications of mass spectrometry to antibiotic research

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