Piezoelectric nanocomposite bioink and ultrasound stimulation modulate early skeletal myogenesis

Author:

Paci Claudia12ORCID,Iberite Federica12ORCID,Arrico Lorenzo12ORCID,Vannozzi Lorenzo12ORCID,Parlanti Paola3ORCID,Gemmi Mauro3ORCID,Ricotti Leonardo12ORCID

Affiliation:

1. The BioRobotics Institute, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy

2. Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy

3. Istituto Italiano di Tecnologia, Center for Materials Interfaces, Electron Crystallography, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy

Abstract

A cell-laden alginate/Pluronic-based bioink doped with BaTiO3 piezoelectric nanoparticles (BTNPs) was investigated. BTNPs promoted myogenic differentiation and the synergy with ultrasound boosted the expression of MYOD1MYOG, and MYH2 genes.

Funder

Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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