Molecular insights into the improved clinical performance of PEGylated interferon therapeutics: a molecular dynamics perspective-Reference-Cited by-同舟云学术

Molecular insights into the improved clinical performance of PEGylated interferon therapeutics: a molecular dynamics perspective

Published:2018 Issue:5 Volume:8 Page:2315-2322
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xu Dong¹²³⁴⁵^ORCID,Smolin Nikolai⁶⁷⁸⁹,Shaw Rance K.¹⁰¹¹⁹,Battey Samuel R.¹²¹³¹⁴⁹,Tao Aoxiang¹²³⁴⁵^ORCID,Huang Yuying¹²³⁴⁵,Rahman Shaikh Emdadur¹²³⁴⁵,Caylor Matthew L.¹²³⁴⁵

Affiliation:

1. Department of Biomedical and Pharmaceutical Sciences

2. College of Pharmacy

3. Kasiska Division of Health Sciences

4. Idaho State University

5. Meridian

6. Department of Cell and Molecular Physiology

7. Loyola University Chicago

8. Maywood

9. USA

10. The Reynolds Law Firm, P.C.

11. Corvallis

12. Department of Chemistry

13. Washington State University

14. Pullman

Abstract

We discovered molecular evidence that links PEGylation to improved clinical performance, yet at the expense of decreased bioactivity. Our computational approach will facilitate PEGylated protein drug design and optimize its overall therapeutic efficacy.

Funder

National Institute of General Medical Sciences

Idaho State University

Boise State University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA12480E

Reference38 articles.

1. Biochemistry of Interferons and Their Actions