Pyrrolo[2,3-e]indazole as a novel chemotype for both influenza A virus and pneumococcal neuraminidase inhibitors

Author:

Egorova Anna1ORCID,Richter Martina2,Khrenova Maria13ORCID,Dietrich Elisabeth2,Tsedilin Andrey1ORCID,Kazakova Elena1ORCID,Lepioshkin Alexander1ORCID,Jahn Birgit2,Chernyshev Vladimir34ORCID,Schmidtke Michaela2,Makarov Vadim1ORCID

Affiliation:

1. Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences (Research Centre of Biotechnology RAS), 33-2 Leninsky Prospect, 119071 Moscow, Russia

2. Department of Medical Microbiology, Section of Experimental Virology, Jena University Hospital, Hans-Knöll-Straße 2, 07745 Jena, Germany

3. Chemistry Department, Lomonosov Moscow State University, 1-3 Leninskie Gory, 119991 Moscow, Russia

4. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences, 31-4 Leninsky Prospect, 119071 Moscow, Russia

Abstract

Pyrrolo[2,3-e]indazole is a promising scaffold for the development of novel neuraminidase inhibitors that are active against influenza A virus and S. pneumoniae.

Funder

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference52 articles.

1. World Health Organization , Influenza (Seasonal) , https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) , accessed 2023-01-23

2. Influenza Pandemics of the 20th Century

3. 2009 H1N1 Influenza

4. The 2009 A (H1N1) influenza virus pandemic: A review

5. The co-pathogenesis of influenza viruses with bacteria in the lung

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