Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

Author:

Brown Cameron J.1234ORCID,McGlone Thomas1234,Yerdelen Stephanie1234,Srirambhatla Vijay1234ORCID,Mabbott Fraser1234,Gurung Rajesh1234,L. Briuglia Maria1234,Ahmed Bilal1234ORCID,Polyzois Hector5234ORCID,McGinty John1234ORCID,Perciballi Francesca1234,Fysikopoulos Dimitris1674,MacFhionnghaile Pól1234,Siddique Humera1234,Raval Vishal1234,Harrington Tomás S.1894ORCID,Vassileiou Antony D.1234ORCID,Robertson Murray1234ORCID,Prasad Elke1234,Johnston Andrea1234ORCID,Johnston Blair1234,Nordon Alison1234ORCID,Srai Jagjit S.1894,Halbert Gavin1234,ter Horst Joop H.1234ORCID,Price Chris J.1234,Rielly Chris D.1674,Sefcik Jan1234,Florence Alastair J.1234ORCID

Affiliation:

1. EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation

2. University of Strathclyde

3. Glasgow

4. UK

5. National Physical Laboratory (NPL) Scotland

6. Loughborough University

7. Loughborough

8. University of Cambridge

9. Cambridge

Abstract

Presentation and applied case study of a system-wide workflow which supports rapid, systematic and efficient continuous seeded cooling crystallisation process design, with the aim to deliver a robust, consistent process with tight control of particle attributes.

Funder

Higher Education Funding Council for England

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

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