Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile-Reference-Cited by-同舟云学术

Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Published:2019 Issue:59 Volume:9 Page:34227-34234
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Agyemang Nana B.¹²³⁴⁵^ORCID,Kukla Cassandra R.⁶⁷⁸⁵,Edwards Tiffany C.⁶⁷⁸⁵,Li Qilan⁶⁷⁸⁵,Langen Madison K.⁹⁷¹⁰⁵,Schaal Alexandra⁹⁷¹⁰⁵,Franson Abaigeal D.⁶⁷⁸⁵,Casals Andreu Gazquez⁶⁷⁸⁵,Donald Katherine A.⁶⁷⁸⁵,Yu Alice J.⁶⁷⁸⁵,Donlin Maureen J.⁹⁷¹⁰⁵^ORCID,Morrison Lynda A.⁶⁷⁸⁵¹¹^ORCID,Tavis John E.⁶⁷⁸⁵^ORCID,Murelli Ryan P.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Brooklyn College

3. The City University of New York

4. New York 11210

5. USA

6. Department of Molecular Microbiology and Immunology

7. Saint Louis University School of Medicine

8. Saint Louis

9. Edward A. Doisy Department of Biochemistry and Molecular Biology

10. St. Louis

11. Department of Internal Medicine

Abstract

A library of α-hydroxytropolones synthesized through a simple halogenation/thiolate addition sequence reveals molecules with potent activity against three human pathogens.

Funder

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Saint Louis University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA06383H

Reference44 articles.

1. The biology and synthesis of α-hydroxytropolones