Imaging mass spectrometry differentiates the effects of doxorubicin formulations on non-targeted tissues

Author:

Debeljak Željko12ORCID,Vinković Vrček Ivana3ORCID,Drinković Nikša4,Micek Vedran3,Galić Emerik5,Gorup Dunja6,Ćurlin Marija7,Mandić Dario12,Bandjak Ana1,Pem Barbara3,Kalčec Nikolina3,Ilić Krunoslav3,Pavičić Ivan3,Mimica Suzana12,Günday-Türeli Nazende8ORCID,Türeli Emre8

Affiliation:

1. University Hospital Osijek, Osijek, Croatia

2. JJ Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia

3. Institute for Medical Research and Occupational Health, Zagreb, Croatia

4. Polyclinic Drinković, Zagreb, Croatia

5. JJ Strossmayer University of Osijek, Faculty of Agrobiotechnical Sciences, Osijek, Croatia

6. University of Zagreb, School of Medicine, Zagreb, Croatia

7. Croatian Catholic University, Zagreb, Croatia

8. MyBiotech, Überherrn, Germany

Abstract

Imaging mass spectrometry indicated a wide range of chemical disturbances in a model of non-targeted organs of rats treated with different formulations of doxorubicin and enabled the differentiation of drug formulation-specific effects.

Funder

Horizon 2020 Framework Programme

European Regional Development Fund

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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