Targeted proximity-labelling of protein tyrosines <i>via</i> flavin-dependent photoredox catalysis with mechanistic evidence for a radical–radical recombination pathway-Reference-Cited by-同舟云学术

Targeted proximity-labelling of protein tyrosines via flavin-dependent photoredox catalysis with mechanistic evidence for a radical–radical recombination pathway

Published:2023 Issue:26 Volume:14 Page:7327-7333
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hope Taylor O.¹,Reyes-Robles Tamara²,Ryu Keun Ah²,Mauries Steven¹,Removski Nicole¹,Maisonneuve Jacinthe¹,Oslund Rob C.²^ORCID,Fadeyi Olugbeminiyi O.²,Frenette Mathieu¹^ORCID

Affiliation:

1. Department of Chemistry, NanoQAM, Centre Québécois des Matériaux Fonctionnels (CQMF), Université du Québec à Montréal, Montréal, Québec, H3C 3P8, Canada

2. Exploratory Science Center, Merck & Co., Inc., Cambridge, MA, USA

Abstract

Labelling of protein tyrosines with phenol-containing tags is shown using riboflavin based-photocatalysts with a smaller labelling radius than peroxidase-based methods. Mechanistic insight also suggests a radical recombination mechanism.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00638G

Reference33 articles.

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