Synthesis of 17-membered azalides from a 16-membered macrolide utilizing amide-selective silane reduction-Reference-Cited by-同舟云学术

Synthesis of 17-membered azalides from a 16-membered macrolide utilizing amide-selective silane reduction

Published:2015 Issue:4 Volume:6 Page:581-585
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Seki Atsushi¹²³,Mori Toshihiro¹²³,Sasaki Kouji¹²³,Takahashi Yoshiaki¹²³,Miyake Toshiaki¹²³,Akamatsu Yuzuru⁴⁵³

Affiliation:

1. Institute of Microbial Chemistry (BIKAKEN)

2. Kawasaki-shi

3. Japan

4. Institute of Microbial Chemistry (BIKAKEN), Tokyo

5. Tokyo 141-0021

Abstract

Novel 17-membered azalides of N-methylated amine type were synthesized and their antibacterial activity was evaluated.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00489B

Reference45 articles.

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2. Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-aza-9a-homoerythromycin A derivatives; A new class of macrolide antibiotics, the azalides.

3. Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement

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