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Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats

  • Published:2015 Issue:4 Volume:6 Page:708-714
  • ISSN:2040-2503
  • Container-title:MedChemComm
  • language:en
  • Short-container-title:Med. Chem. Commun.

Author:

Olberg Dag Erlend123,Hausner Sven H.45678,Bauer Nadine4567,Klaveness Jo9103,Indrevoll Bård11123,Andressen Kjetil Wessel131415163,Dahl Marie131415163,Levy Finn Olav131415163,Sutcliffe Julie L.45678,Haraldsen Ira1718163

Affiliation:

1. Norsk Medisinsk Syklotronsenter AS

2. 0027 Oslo

3. Norway

4. Department of Biomedical Engineering

5. University of California Davis

6. Davis

7. USA

8. Department of Internal Medicine

9. School of Pharmacy

10. University of Oslo

11. GE Healthcare AS

12. 0401 Oslo

13. Department of Pharmacology

14. Faculty of Medicine

15. University of Oslo and Oslo University Hospital

16. Oslo

17. Department of Neuropsychiatry and Psychosomatic Medicine

18. Oslo University Hospital

Abstract

A series of high affinity 18F-GnRH peptides have been synthesized and show utility as imaging agents for GnRH receptor expression in vivo.

Funder

Office of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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