Water-mediated reduction of [Cu(dmp)2(CH3CN)]2+: implications of the structure of a classical complex on its activity as an anticancer drug-Reference-Cited by-同舟云学术

Water-mediated reduction of [Cu(dmp)2(CH3CN)]2+: implications of the structure of a classical complex on its activity as an anticancer drug

Published:2021 Issue: Volume: Page:
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Levín Pedro¹²³⁴⁵^ORCID,Ruiz María C.⁶⁷⁸,Romo Adolfo I. B.⁹¹⁰¹¹,Nascimento Otaciro R.¹²¹³¹⁴¹¹,Di Virgilio Ana L.⁶⁷⁸,Oliver Allen G.¹⁵¹⁶¹⁷¹⁸,Ayala Alejandro P.¹⁹¹⁰¹¹^ORCID,Diógenes Izaura C. N.⁹¹⁰¹¹^ORCID,León Ignacio E.⁶⁷⁸^ORCID,Lemus Luis¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química de los Materiales

2. Facultad de Química y Biología

3. Universidad de Santiago de Chile

4. Santiago

5. Chile

6. Centro de Química Inorgánica CEQUINOR (CONICET-UNLP)

7. La Plata

8. Argentina

9. Departamento de Química Orgânica e Inorgânica Universidade Federal do Ceará

10. Fortaleza

11. Brazil

12. Departamento de Física Interdiciplinar

13. Instituto de Física de São Carlos Universidade de São Paulo

14. CEP 13560-970 São Carlos

15. Department of Chemistry and Biochemistry

16. University of Notre Dame

17. 46556-5670 Notre Dame

18. USA

19. Departamento de Física Universidade Federal do Ceará

Abstract

[Cu(dmp)₂(CH₃CN)]²⁺ can be reduced in acetonitrile containing water due to steric constraints of the ligands. Hydroxyl radicals are produced from water oxidation. We take advantage of this reaction to evaluate the anticancer activity of the complex.

Funder

Universidad de Santiago de Chile

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Consejo Nacional de Investigaciones Científicas y Técnicas

Fondo Nacional de Desarrollo Científico y Tecnológico

Comisión Nacional de Investigación Científica y Tecnológica

Agencia Nacional de Promoción Científica y Tecnológica

Universidad Nacional de La Plata

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry