Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip-Reference-Cited by-同舟云学术

Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip

Published:2023 Issue:1 Volume:23 Page:168-181
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

de Graaf Mees N. S.¹^ORCID,Vivas Aisen²³^ORCID,Kasi Dhanesh G.¹⁴⁵,van den Hil Francijna E.¹,van den Berg Albert³^ORCID,van der Meer Andries D.²^ORCID,Mummery Christine L.¹²^ORCID,Orlova Valeria V.¹^ORCID

Affiliation:

1. Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

2. Applied Stem Cell Technologies, University of Twente, 7500AE Enschede, The Netherlands

3. BIOS Lab on a Chip Group, MESA+ Institute for Nanotechnology, Technical Medical Centre, Max Planck Institute for Complex Fluid Dynamics, University of Twente, 7500AE Enschede, The Netherlands

4. Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

5. Department of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

Abstract

We developed a fluidic circuit board for simultaneous perfusion of up to twelve 3D vessels-on-a-chip under comparable wall shear stress using a single set of control parameters despite high intrinsic sample diameter variation.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC00686C

Reference65 articles.

1. Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

2. Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling