Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway-Reference-Cited by-同舟云学术

Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway

Published:2015 Issue:11 Volume:11 Page:2878-2884
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Zhang Shouyue¹²³⁴⁵,Li Jie⁶⁷⁸⁴,Song Sicheng⁵⁹¹⁰³⁴,Li Jing⁵⁹¹⁰³⁴,Tong Rongsheng¹²³⁴,Zang Zhihe¹¹¹²³⁴,Jiang Qinglin¹¹¹²³⁴,Cai Lulu¹²³⁴⁵

Affiliation:

1. Department of Pharmacy

2. Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital

3. Chengdu

4. P. R. China

5. School of Life Sciences and State Key Laboratory of Biotherapy

6. School of Medicine

7. Zhejiang University City College

8. Hangzhou 310015

9. West China Hospital

10. Sichuan University

11. College of Pharmacy

12. Chengdu Medical College

Abstract

The proteomic analysis integrated signalling network analysis suggested that the Wnt/β-catenin signalling pathway was a novel target of Arctigenin.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00439J

Reference40 articles.

1. Identification of Arctigenin as an Antitumor Agent Having the Ability to Eliminate the Tolerance of Cancer Cells to Nutrient Starvation

2. Arctigenin alleviates ER stress via activating AMPK

3. Dibenzylbutyrolactone Lignans from Forsythia koreana Fruits Attenuate Lipopolysaccharide-Induced Inducible Nitric Oxide Synthetase and Cyclooxygenase-2 Expressions through Activation of Nuclear Factor-.KAPPA.B and Mitogen-Activated Protein Kinase in RAW264.7 Cells

4. Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan

5. Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways

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1. Arctigenin: pharmacology, total synthesis, and progress in structure modification;Journal of Enzyme Inhibition and Medicinal Chemistry;2022-09-12

2. Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor;Scientific Reports;2020-01-29

3. Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro;Frontiers in Pharmacology;2019-08-29

4. The antitumor function of arctigenin in human retinoblastoma cells is mediated by jagged‑1;Molecular Medicine Reports;2019-03-14

5. The anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of ER expression;International Journal of Oncology;2016-12-29