Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2
Author:
Affiliation:
1. Schulich Faculty of Chemistry
2. Technion-Israel Institute of Technology
3. Haifa
4. Israel
Abstract
A multidisciplinary approach, composed of organic synthesis, electrochemistry, electrocatalysis and cellular studies, for correlating the molecular features of a 1,2-naphthoquinone scaffold with its ROS generating ability.
Funder
Ministry of Science,Technology and space
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC02758J
Reference37 articles.
1. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2. Photodynamic therapy: a clinical reality in the treatment of cancer
3. Reactive oxygen species in cancer
4. Selective killing of cancer cells by a small molecule targeting the stress response to ROS
5. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
Cited by 30 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells;Chinese Chemical Letters;2024-02
2. Novel NQO1 substrates bearing two nitrogen redox centers: Design, synthesis, molecular dynamics simulations, and antitumor evaluation;Bioorganic Chemistry;2023-05
3. Ubiquitin specific peptidases and prostate cancer;PeerJ;2023-02-16
4. YM155 inhibits neuroblastoma growth through degradation of MYCN: A new role as a USP7 inhibitor;European Journal of Pharmaceutical Sciences;2023-02
5. Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade;Molecules;2022-11-28
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3