Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones-Reference-Cited by-同舟云学术

Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones

Published:2015 Issue:15 Volume:13 Page:4514-4523
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Gilfillan Lynne¹²³⁴⁵,Artschwager Raik¹²³⁴⁵,Harkiss Alexander H.¹²³⁴⁵,Liskamp Rob M. J.¹²³⁴⁵,Sutherland Andrew¹²³⁴⁵

Affiliation:

1. WestCHEM

2. School of Chemistry

3. The Joseph Black Building

4. University of Glasgow

5. Glasgow

Abstract

A new class of α-amino acid incorporating 5-aryl pyrazole units have been prepared using a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00364D

Reference50 articles.

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4. Asymmetric synthesis of β-hydroxy-α-alkylamino acids by asymmetric aldol reaction of α-isocyanocarboxylates catalyzed by chiral ferrocenylphosphine-gold(I) complexes

5. R. M. Williams , Synthesis of Optically Active α-Amino Acids, Pergamon Press, Oxford, 1989, vol. 7

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