Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes: in vitro anti-proliferative and anti-invasive activity in glioblastoma-Reference-Cited by-同舟云学术

Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes: in vitro anti-proliferative and anti-invasive activity in glioblastoma

Published:2019 Issue:53 Volume:9 Page:30976-30988
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Alshaer Walhan¹²³⁴^ORCID,Zraikat Manar⁵⁶²³⁴,Amer Amer⁷⁸²³⁴,Nsairat Hamdi⁹¹⁰²³⁴,Lafi Zainab⁷⁸²³⁴,Alqudah Dana A.¹²³⁴,Al Qadi Enas⁵⁶²³⁴,Alsheleh Tasneem⁵⁶²³⁴,Odeh Fadwa⁹¹⁰²³⁴,Alkaraki Arwa¹²³⁴⁵,Zihlif Malek⁵⁶²³⁴,Bustanji Yasser⁷⁸²³⁴,Fattal Elias¹¹¹²¹³¹⁴¹⁵^ORCID,Awidi Abdalla¹²³⁴¹⁶

Affiliation:

1. Cell Therapy Center

2. The University of Jordan

3. Amman

4. Jordan

5. Department of Pharmacology

6. Faculty of Medicine

7. Department of Clinical Pharmacy

8. Faculty of Pharmacy

9. Department of Chemistry

10. Faculty of Science

11. Institut Galien Paris-Sud

12. CNRS

13. Université Paris-Sud

14. Université Paris-Saclay

15. France

16. Department of Hematology

Abstract

Echinomycin, a DNA bis-intercalator peptide antibiotic, was complexed with γCD and loaded into PEGylated liposomes. The liposomes encapsulating echinomycin showed potent anti-proliferative and anti-invasive effect against U-87 MG glioblastoma cells.

Funder

University of Jordan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA05636J

Reference68 articles.

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2. Echinomycin: The first bifunctional intercalating agent in clinical trials

3. K. Katagiri , T.Yoshida and K.Sato , in Mechanism of action of antimicrobial and antitumor agents , Springer , 1975 , pp. 234–251