Stephapierrines A–H, new tetrahydroprotoberberine and aporphine alkaloids from the tubers of Stephania pierrei Diels and their anti-cholinesterase activities

Author:

Chaichompoo Waraluck12345,Rojsitthisak Pornchai12345ORCID,Pabuprapap Wachirachai67895ORCID,Siriwattanasathien Yuttana67895,Yotmanee Pathumwadee67895,Haritakun Woraphot101112135,Suksamrarn Apichart67895ORCID

Affiliation:

1. Department of Food and Pharmaceutical Chemistry

2. Faculty of Pharmaceutical Sciences

3. Chulalongkorn University

4. Bangkok 10330

5. Thailand

6. Department of Chemistry and Center of Excellence for Innovation in Chemistry

7. Faculty of Science

8. Ramkhamhaeng University

9. Bangkok 10240

10. Program in Chemical Technology

11. Faculty of Science and Technology

12. Suan Dusit University

13. Bangkok 10700

Abstract

Eight new alkaloids 1–8, together with three new naturally occurring alkaloids and thirty-four known alkaloids were isolated. Five compounds exhibited more potent anti-cholinesterase activities than galanthamine, the reference drug.

Funder

Chulalongkorn University

Thailand Research Fund

Center of Excellence for Innovation in Chemistry

Thailand Science Research and Innovation

Ministry of Higher Education, Science, Research and Innovation, Thailand

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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