Multifunctional porous microspheres encapsulating oncolytic bacterial spores and their potential for cancer immunotherapy

Author:

Bae Ga-Hyun1ORCID,Ryu Young-Hyun23ORCID,Han Jieun14,Kim Song Hee5,Park Chun Gwon6789,Park Jung-Hoon5,Kim Dong-Hyun10111213ORCID,Chon Hong Jae1415,Kim Chan1415,Choi Sung-Wook23ORCID,Park Wooram14ORCID

Affiliation:

1. Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon, Gyeonggi 16419, Republic of Korea

2. Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea

3. Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea

4. Institute of Biotechnology and Bioengineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon, Gyeonggi 16419, Republic of Korea

5. Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea

6. Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea

7. Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea

8. Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Gyeonggi 16419, Republic of Korea

9. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea

10. Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA

11. Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA

12. Department of Biomedical Engineering, McCormick School of Engineering, Evanston, Illinois, 60208, USA

13. Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, 60607, USA

14. Medical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi 13496, Republic of Korea

15. Laboratory of Translational Immunology, CHA University School of Medicine, Seongnam, Gyeonggi 13496, Republic of Korea

Abstract

Multifunctional porous microspheres (MPMs) containing oncolytic bacterial spores provide a promising strategy for targeted cancer immunotherapy.

Funder

Korea Medical Device Development Fund

Ministry of Science and ICT, South Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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