Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells-Reference-Cited by-同舟云学术

Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells

Published:2023 Issue:7 Volume:19 Page:585-597
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Gederaas Odrun A.¹²^ORCID,Sharma Animesh¹³,Mbarak Saide¹,Sporsheim Bjørnar¹⁴,Høgset Anders⁵,Bogoeva Vanya⁶,Slupphaug Geir¹³^ORCID,Hagen Lars¹³

Affiliation:

1. Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, N-7489 Trondheim, Norway

2. Department of Natural Sciences, UiA, University of Agder, N-4630, Kristiansand, Norway

3. Proteomics and Modomics Experimental Core, PROMEC, at NTNU and the Central Norway Regional Health Authority, Trondheim, Norway

4. CMIC Cellular & Molecular Imaging Core Facility, Norwegian University of Science and Technology, NTNU, and the Central Norway Regional Health Authority Norway, Trondheim, Norway

5. PCI Biotech AS, Ullernchaussen 64, 0379 Oslo, Norway

6. Department of Molecular Biology and Cell Cycle, Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Abstract

SILAC-proteome analysis of rat bladder cancer cells using bleomycin (BML) and photochemical internalization (PCI); fimaporfin. BLMPCIdownregulates bleomycin hydrolase, mediates synergistic cytotoxic effect and affects several cellular responses.

Funder

Bulgarian National Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MO/D2MO00337F

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5. Nucleic Acid Recognition by Metal Complexes of Bleomycin

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