Ruthenium based antimicrobial theranostics – using nanoscopy to identify therapeutic targets and resistance mechanisms inStaphylococcus aureus-Reference-Cited by-同舟云学术

Ruthenium based antimicrobial theranostics – using nanoscopy to identify therapeutic targets and resistance mechanisms inStaphylococcus aureus

Published:2020 Issue:1 Volume:11 Page:70-79
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Smitten Kirsty L.¹²³⁴⁵^ORCID,Fairbanks Simon D.¹²³⁴,Robertson Craig C.¹²³⁴,Bernardino de la Serna Jorge⁶⁷⁸⁹⁴^ORCID,Foster Simon J.⁵²⁴^ORCID,Thomas Jim A.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Sheffield

3. Sheffield S10 2TN

4. UK

5. The Florey Institute and Department of Molecular Biology and Biotechnology

6. National Heart and Lung Institute

7. Faculty of Medicine

8. Imperial College London

9. London SW7 2AZ

Abstract

A detailed study on the uptake and antimicrobial activity of a Ru^IItheranostic complex with wild-typeS. aureus, MRSA, and other mutants has identified the specific resistance mechanisms that Gram-positive bacteria display against this lead.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04710G

Reference86 articles.

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2. World Health Organization , Antimicrobial resistance: global report on surveillance , 2014

3. Antimicrobial Resistance Is a Global Health Emergency