Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives-Reference-Cited by-同舟云学术

Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives

Published:2018 Issue:11 Volume:9 Page:1910-1919
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zhang Yumeng¹²³⁴,Yuan Weihui¹²³⁴,Wang Xude¹²³⁴,Zhang Hongyu¹²³⁴,Sun Yuanyuan¹²³⁴,Zhang Xiaoshu¹²³⁴⁵,Zhao Yuqing¹²³⁴⁵^ORCID

Affiliation:

1. Department of Traditional Chinese Medicine Chemical

2. Shenyang Pharmaceutical University

3. Shenyang 110016

4. China

5. Key Laboratory of Structure-based Drug Design and Discovery

Abstract

Compounds 1j and 2f possessed excellent anti-proliferative activities while having much weaker effect on the growth of normal cells and they can be promising lead candidates for further studies.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00387D

Reference26 articles.

1. Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells

2. Antitumor Activities and Immunomodulatory Effects of Ginseng Neutral Polysaccharides in Combination with 5-Fluorouracil

3. Protective effects of ginsenoside Rb3 on oxygen and glucose deprivation-induced ischemic injury in PC12 cells

4. Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells

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