A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy
Author:
Affiliation:
1. Institute for Chemical Biology & Drug Discovery
2. Department of Chemistry
3. Stony Brook University
4. Stony Brook
5. USA
6. C4 Therapeutics
7. Cambridge
Abstract
Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03306G
Reference36 articles.
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