Synthesis of rhamnosylated arginine glycopeptides and determination of the glycosidic linkage in bacterial elongation factor P-Reference-Cited by-同舟云学术

Synthesis of rhamnosylated arginine glycopeptides and determination of the glycosidic linkage in bacterial elongation factor P

Published:2017 Issue:3 Volume:8 Page:2296-2302
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Siyao¹²³⁴,Corcilius Leo¹²³⁴,Sharp Phillip P.⁵⁶⁴,Rajkovic Andrei⁷⁸⁹¹⁰,Ibba Michael⁷⁸⁹¹⁰^ORCID,Parker Benjamin L.¹¹²⁴,Payne Richard J.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. The University of Sydney

3. Sydney

4. Australia

5. ACRF Chemical Biology Division

6. Walter and Eliza Hall Institute of Medical Research

7. Department of Microbiology and Center for RNA Biology

8. Ohio State University

9. Columbus

10. USA

11. Charles Perkins Centre

Abstract

We describe the synthesis and incorporation of α- and β-configured rhamnosyl arginine cassettes into Pseudomonas aeruginosa elongation factor P-derived glycopeptides. These were used to unequivocally determine the native anomeric configuration of the rhamnose moiety in EF-P.

Funder

Australian Research Council

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03847F

Reference31 articles.

1. On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database

2. Vertebrate protein glycosylation: diversity, synthesis and function