Photochemical difluoromethylation of alkynes: synthesis of CF<sub>2</sub>H-substituted seven-membered dioxodibenzothiazepines and dibenzazepines-Reference-Cited by-同舟云学术

Photochemical difluoromethylation of alkynes: synthesis of CF₂H-substituted seven-membered dioxodibenzothiazepines and dibenzazepines

Published:2023 Issue:8 Volume:10 Page:1968-1974
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Xiaoyu¹,Geng Yang²,Liu Bo¹,Zhu Yu¹,Zou Dapeng¹,Wu Yangjie¹^ORCID,Wu Yusheng¹³⁴^ORCID

Affiliation:

1. College of Chemistry, Green Catalysis Center, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, 450001, People's Republic of China

2. Department of Pharmacy, Zhengzhou Railway Vocational and Technical College, Zhengzhou, 451460, People's Republic of China

3. TYK Medicines, Inc., Huzhou, 313000, People's Republic of China

4. Tetranov International, Inc., New Brunswick, New Jersey 08901, USA

Abstract

A general and efficient photochemical strategy for difluoromethylation/radical cascade cyclization of alkynes with sodium difluoromethylsulfinate (NaSO2CF2H) has been disclosed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00020F

Reference59 articles.

1. Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

2. Late-stage difluoromethylation: concepts, developments and perspective

3. CF2H, a Hydrogen Bond Donor