Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones
Author:
Affiliation:
1. Department of Chemistry
2. Johannes Gutenberg-University
3. 55128 Mainz
4. Germany
5. Department of Molecular Biotechnology & Systems Biology
6. University of Kaiserslautern
7. 67663 Kaiserslautern
Abstract
Seven new macrolactones of the oxacyclododecindione family have been synthesized and tested for their inhibitory activity on TGF-β-inducible Smad2/3- as well as IL-4-inducible STAT6-dependent signalling pathways.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00958J
Reference27 articles.
1. Oxacyclododecindione, a Novel Inhibitor of IL-4 Signaling from Exserohilum rostratum
2. A new cytotoxic 12-membered macrolactone from the endophytic fungus Exserohilum rostratum LPC-001
3. 4-Dechloro-14-deoxy-oxacyclododecindione and 14-deoxy-oxacylododecindione, two inhibitors of inducible connective tissue growth factor expression from the imperfect fungus Exserohilum rostratum
4. A surprising switch in absolute configuration of anti-inflammatory macrolactones
5. Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone
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