Tumor-targeted dual-action NSAID-platinum(<scp>iv</scp>) anticancer prodrugs-Reference-Cited by-同舟云学术

Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs

Published:2023 Issue:14 Volume:10 Page:4126-4138
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Kastner Alexander¹²^ORCID,Mendrina Theresa¹³⁴,Bachmann Florian¹^ORCID,Berger Walter³⁴^ORCID,Keppler Bernhard K.¹⁴,Heffeter Petra³⁴^ORCID,Kowol Christian R.¹⁴^ORCID

Affiliation:

1. University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, 1090 Vienna, Austria

2. University of Vienna, Vienna Doctoral School in Chemistry (DoSChem), Waehringer Str. 42, 1090 Vienna, Austria

3. Center of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria

4. Research Cluster “Translational Cancer Therapy Research”, 1090 Vienna, Austria

Abstract

We investigated the first oxaliplatin(iv) complexes releasing acetylsalicylic acid (aspirin) upon reduction. The albumin-targeted derivative showed distinctly improved antitumor activity compared to asplatin, a recently reported cisplatin(iv) analog.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QI/D3QI00968H

Reference40 articles.

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