Probing the serum albumin binding site of fenamates and photochemical protein labeling with a fluorescent dye-Reference-Cited by-同舟云学术

Probing the serum albumin binding site of fenamates and photochemical protein labeling with a fluorescent dye

Published:2022 Issue:25 Volume:20 Page:5076-5085
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Deng Tao¹²^ORCID,Zhao Jing¹,Peng Danfeng¹,He Xinqian¹^ORCID,Huang Xin-an¹²,Lin Chaozhan³,Zhu Chenchen³,Wang Lei⁴,Liu Fang³^ORCID

Affiliation:

1. Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

2. Lingnan Medical Research Center, the first Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

3. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

4. Department of Cardiology, the 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

Abstract

A fluorescent probe TTPy has been prepared that can target the HSA binding site of fenamates, a group of non-steroidal anti-inflammatory drugs (NSAIDs). In addition, TTPy enables HSA fluorescent labeling upon visible light irradiation.

Funder

National Natural Science Foundation of China

Department of Education of Guangdong Province

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00717G

Reference64 articles.

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