A combined experimental and computational study on the interaction of nitrogen mustards with DNA-Reference-Cited by-同舟云学术

A combined experimental and computational study on the interaction of nitrogen mustards with DNA

Published:2016 Issue:10 Volume:7 Page:2003-2015
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Bonsaii Mahyar¹²³⁴^ORCID,Gholivand Khodayar¹⁵³⁴,Abdi Khosrou⁶⁷³⁴,Valmoozi Ali Asghar Ebrahimi¹⁵³⁴,Khosravi Morteza¹²³⁴

Affiliation:

1. Department of Chemistry

2. Islamic Azad University

3. Tehran

4. Iran

5. Tarbiat Modares University

6. Department of Medicinal Chemistry and Radiopharmacy

7. Tehran University of Medical Sciences

Abstract

In the present work, we suggest that the role of water in the reaction of nitrogen mustards with DNA is more than what was thought before. Nitrogen mustards become activated when they are hydrated by water.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00264A

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