A robust heterogeneous chiral phosphoric acid enables multi decagram scale production of optically active <i>N</i>,<i>S</i>-ketals-Reference-Cited by-同舟云学术

A robust heterogeneous chiral phosphoric acid enables multi decagram scale production of optically active N,S-ketals

Published:2024 Issue:8 Volume:26 Page:4593-4599
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Maestro Aitor¹²^ORCID,Malviya Bhanwar K.²³,Auer Gerald⁴,Ötvös Sándor B.²³^ORCID,Kappe C. Oliver²³^ORCID

Affiliation:

1. Department of Organic Chemistry I, University of the Basque Country, UPV/EHU, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain

2. Institute of Chemistry, University of Graz, NAWI Graz, A-8010 Graz, Austria

3. Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), A-8010 Graz, Austria

4. Department of Earth Sciences, University of Graz, NAWI Graz Geocenter, A-8010 Graz, Austria

Abstract

A multi-decagram scale synthesis of enantioenriched N,S-ketals was achieved by using a robust heterogeneous organocatalyst. A new reactor design was crucial to enable the scaling up of this reaction while the overall catalyst loading below 0.1%.

Funder

Eusko Jaurlaritza

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/GC/D4GC00019F

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