A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy-Reference-Cited by-同舟云学术

A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy

Published:2021 Issue:15 Volume:9 Page:3335-3345
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Tan Chen¹²³⁴⁵^ORCID,Jia Fan⁶⁷⁸⁹¹⁰^ORCID,Zhang Peng⁶⁷⁸⁹¹⁰,Sun Xinghuai¹²³⁴⁵,Qiao Yunsheng¹²³⁴⁵,Chen Xueli¹²³⁴⁵,Wang Youxiang⁶⁷⁸⁹¹⁰^ORCID,Chen Junyi¹²³⁴⁵,Lei Yuan¹²³⁴⁵

Affiliation:

1. Department of Ophthalmology & Visual Science

2. Eye & ENT Hospital

3. Shanghai Medical College

4. Fudan University

5. Shanghai 200031

6. MOE Key Laboratory of Macromolecular Synthesis and Functionalization

7. Department of Polymer Science and Engineering

8. Zhejiang University

9. Hangzhou, 310027

10. P. R. China

Abstract

Polydopamine–polyethylenimine nanoparticles (PDA/PEI NPs) have been successfully applied as miRNA carriers, and PDA/PEI NPs/miR-21-5p plays a role in increasing the aqueous humor drainage and lowering the intraocular pressure.

Funder

BrightFocus Foundation

Shanghai Shenkang Hospital Development Center

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D0TB02881A

Reference42 articles.

1. The Pathophysiology and Treatment of Glaucoma