A digital workflow from crystallographic structure to single crystal particle attributes for predicting the formulation properties of terbutaline sulfate-Reference-Cited by-同舟云学术

A digital workflow from crystallographic structure to single crystal particle attributes for predicting the formulation properties of terbutaline sulfate

Published:2020 Issue:19 Volume:22 Page:3347-3360
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Nguyen Thai T. H.¹²³⁴⁵^ORCID,Hammond Robert B.¹²³⁴⁵^ORCID,Styliari Ioanna D.⁶⁷⁵^ORCID,Murnane Darragh⁶⁷⁵^ORCID,Roberts Kevin J.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for the Digital Design of Drug Products

2. School of Chemical and Process Engineering

3. University of Leeds

4. Leeds

5. UK

6. School of Life and Medical Sciences

7. University of Hertfordshire

Abstract

A detailed inter-molecular (synthonic) analysis of terbutaline sulfate, an ionic addition salt for inhalation drug formulation, is related to its crystal morphology, the surface chemistry of the habit faces and hence to its crystal surface energy.

Funder

Engineering and Physical Sciences Research Council

Pfizer UK

Novartis Pharmaceuticals UK Limited

Boehringer Ingelheim

Syngenta International

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CE/D0CE00026D