Exploring interfacial dynamics in homodimeric S-ribosylhomocysteine lyase (LuxS) from Vibrio cholerae through molecular dynamics simulations-Reference-Cited by-同舟云学术

Exploring interfacial dynamics in homodimeric S-ribosylhomocysteine lyase (LuxS) from Vibrio cholerae through molecular dynamics simulations

Published:2021 Issue:3 Volume:11 Page:1700-1714
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bux Khair¹²³⁴⁵,Hofer Thomas S.⁶⁷⁸⁹¹⁰^ORCID,Moin Syed Tarique¹²³⁴⁵^ORCID

Affiliation:

1. H.E.J. Research Institute of Chemistry

2. International Center for Chemical and Biological Sciences

3. University of Karachi

4. Karachi-75270

5. Pakistan

6. Theoretical Chemistry Division

7. Institute of General, Inorganic and Theoretical Chemistry

8. University of Innsbruck

9. A-6020 Innsbruck

10. Austria

Abstract

To the best of our knowledge, this is the first molecular dynamics simulation study on the dimeric form of the LuxS enzyme from Vibrio cholerae to evaluate its structural and dynamical properties including the dynamics of the interface formed by the two monomeric chains of the enzyme.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA08809A

Reference76 articles.

1. Evolution of Resistance to Quorum-Sensing Inhibitors

2. Quorum sensing in fungi – a review

3. luxS-Based Quorum-Sensing Signaling Affects Biofilm Formation in Streptococcus mutans

4. Role of the luxS Quorum-Sensing System in Biofilm Formation and Virulence of Staphylococcus epidermidis

5. LuxS quorum sensing: more than just a numbers game

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