Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot

Author:

Kasse Catherine M.1ORCID,Yu Anthony C.1,Powell Abigail E.23,Roth Gillie A.4ORCID,Liong Celine S.4,Jons Carolyn K.1,Buahin Awua1,Maikawa Caitlin L.4ORCID,Zhou Xueting4,Youssef Sawsan5,Glanville Jacob E.5,Appel Eric A.13467ORCID

Affiliation:

1. Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA

2. Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA

3. Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA

4. Department of Bioengineering, Stanford University, Stanford, CA, 94305 USA

5. Centivax Inc., 329 Oyster Point Drive, 3rd Floor South San Francisco, CA 94080, USA

6. Institute for Immunity, Transplantation, & Infection, Stanford University School of Medicine, Stanford, CA 94305, USA

7. Department of Pediatrics – Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA

Abstract

Prolonged maintenance of therapeutically-relevant levels of broadly neutralizing antibodies (bnAbs) is necessary to enable passive immunization against infectious disease.

Funder

Stanford Maternal and Child Health Research Institute

National Defense Science and Engineering Graduate

National Science Foundation

Bill and Melinda Gates Foundation

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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