Cinnamaldehyde–cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde in vitro anti-tumor activity

Author:

Al Tbakhi Bayan1,Nsairat Hamdi2ORCID,Alshaer Walhan3ORCID,Al-Kadash Abdulfattah4ORCID,Helal Wissam1ORCID,Alrawashdeh Lubna5,Day Anthony6ORCID,Assaf Khaleel I.7ORCID,Hassouneh Rola1,Odeh Fadwa1ORCID,Al Bawab Abeer18

Affiliation:

1. Department of Chemistry, School of Science, The University of Jordan, Amman 11942, Jordan

2. Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan

3. Cell Therapy Center, The University of Jordan, Amman 11942, Jordan

4. School of Medicine, The University of Jordan, Amman 11942, Jordan

5. Department of Chemistry, Faculty of Science, The Hashemite University, P. O. Box 330127, Zarqa 13133, Jordan

6. School of Science, The University of New South Wales, Canberra, ACT 2600, Australia

7. Department of Chemistry, Al-Balqa Applied University, Al-Salt 19117, Jordan

8. Hamdi Mango Center for Scientific Research, The University of Jordan, Amman 11942, Jordan

Abstract

This study aimed to clarify the physico-chemical properties of cucurbit[7]uril (CB[7]) and cinnamaldehyde (Cinn) inclusion complexes (CB[7]–Cinn) and their resulting antitumor activity.

Funder

Deanship of Academic Research, University of Jordan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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