Improving the potential of paraCEST through magnetic-coupling induced line sharpening

Author:

Guo Xin1,Zhang Lei23,Hu Jiesheng1,Szilágyi Balázs45,Yu Meng1ORCID,Chen Shizhen23,Tircsó Gyula4ORCID,Zhou Xin23ORCID,Tao Jun1ORCID

Affiliation:

1. Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology, Beijing 102488, China

2. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary

5. Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary

Abstract

A paramagnetic chemical exchange saturation transfer (paraCEST) imaging agent based on a homodinuclear Ni(ii) complex exhibits enhanced CEST efficiency due to magnetic-coupling induced line sharpening effect.

Funder

National Natural Science Foundation of China

Debreceni Egyetem

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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