Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with DNA damage and apoptosis inducing abilities-Reference-Cited by-同舟云学术

Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with DNA damage and apoptosis inducing abilities

Published:2017 Issue:6 Volume:8 Page:1213-1219
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Liu Ji¹²³⁴,Wang Tingting¹²³⁴,Wang Xinyang¹²³⁴⁵,Luo Lin¹²³⁴,Guo Jing¹²³⁴,Peng Yanfu¹²³⁴,Xu Qibing¹²³⁴,Miao Jiefei¹²³⁴⁶,Zhang Yanan¹²³⁴,Ling Yong¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target

2. Nantong University

3. Nantong 226001

4. P.R. China

5. State Key Laboratory of Natural Medicines

6. Tumor-chemotherapy Department

Abstract

A series of novel β-carboline-based hydroxamate derivatives (8a–n) as HDAC inhibitors have been designed and synthesized.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00681G

Reference31 articles.

1. DNA and its associated processes as targets for cancer therapy

2. Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy

3. Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted Cytotoxicity

4. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”

5. DNA-binding affinity and anticancer activity of β-carboline–chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of Novel β-Carboline/Furylmalononitrile Hybrids as Type I/II Photosensitizers with Chemo-Photodynamic Therapy and Minimal Toxicity;Molecular Pharmaceutics;2024-05-31

2. 1,3-Substituted β-Carboline Derivatives as Potent Chemotherapy for the Treatment of Cystic Echinococcosis;Journal of Medicinal Chemistry;2023-12-09

3. Study of Drug Delivery Using Purely Organic Macrocyclic Containers─Cucurbit[7]uril and Pillararene;ACS Omega;2023-12-04

4. Rational design of β-carboline as an efficient type I/II photosensitizer to enable hypoxia-tolerant chemo-photodynamic therapy;Bioorganic Chemistry;2023-12

5. Selective HDAC3 Inhibitors with Potent In Vivo Antitumor Efficacy against Triple-Negative Breast Cancer;Journal of Medicinal Chemistry;2023-09-03