Synthesis of the tumor associative α-aminooxy disaccharide of the TF antigen and its conjugation to a polysaccharide immune stimulant-Reference-Cited by-同舟云学术

Synthesis of the tumor associative α-aminooxy disaccharide of the TF antigen and its conjugation to a polysaccharide immune stimulant

Published:2014 Issue:11 Volume:12 Page:1699-1702
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bourgault Jean Paul¹²³,Trabbic Kevin R.¹²³,Shi Mengchao¹²³,Andreana Peter R.¹²³

Affiliation:

1. Department of Chemistry and School of Green Chemistry and Engineering

2. The University of Toledo

3. Toledo, USA

Abstract

The α-aminooxy derivative of the Thomsen–Friedenriech tumor-associated carbohydrate antigen has been synthesized in 11 steps. This nucleophilic sugar was then utilized in the preparation of the TF-PS A1 conjugate vaccine candidate through oxime bond formation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00128A

Reference42 articles.

1. Cancer vaccines and carbohydrate epitopes

2. Galectin-3 Interaction with Thomsen-Friedenreich Disaccharide on Cancer-associated MUC1 Causes Increased Cancer Cell Endothelial Adhesion

3. The Tn Antigen-Structural Simplicity and Biological Complexity

4. The oncofetal Thomsen–Friedenreich carbohydrate antigen in cancer progression

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