Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol-Reference-Cited by-同舟云学术

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Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol

Published:2024 Issue:4 Volume:14 Page:2741-2744
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Cocco Emanuele¹^ORCID,Iapadre Debora¹^ORCID,Brusa Alessandro¹^ORCID,Allegrini Pietro²^ORCID,Thomas Stephen P.³^ORCID,Pesciaioli Fabio¹^ORCID,Carlone Armando¹⁴^ORCID

Affiliation:

1. Department of Physical and Chemical Sciences, Università degli Studi dell’Aquila, via Vetoio, 67100, L'Aquila, Italy

2. Indena SpA, viale Ortles, 12, 20139 Milan, Italy

3. EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, UK

4. INSTM, Consorzio Nazionale per la Scienza e Tecnologia dei Materiali, RU L'Aquila, Italy

Abstract

A Piers–Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-hydroxy cannabidiol from commercially available cannabidiol, in 31% overall yield.

Funder

Royal Society of Chemistry

Ministero dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA08392F

Reference23 articles.

1. Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer’s disease

2. Stereoselective Synthetic Strategies to (−)‐Cannabidiol

3. Catalytic asymmetric synthesis of cannabinoids and menthol from neral

4. Cytochrome P450–Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol

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