Rapid mild macrocyclization of depsipeptides under continuous flow: total syntheses of five cyclodepsipeptides-Reference-Cited by-同舟云学术

Rapid mild macrocyclization of depsipeptides under continuous flow: total syntheses of five cyclodepsipeptides

Published:2022 Issue:23 Volume:9 Page:6640-6645
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liao Jingyuan¹^ORCID,Jia Xuelei¹²,Wu Fusong¹,Huang Junrong¹,Shen Guifu²,You Hengzhi¹³^ORCID,Chen Fen-Er¹³⁴^ORCID

Affiliation:

1. School of science, Harbin Institute of Technology (Shenzhen), Guangdong, China

2. Shenzhen Zhonghe Headway Bio-Sci & Tech Co., Ltd, Guangdong, China

3. Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology (Shenzhen), Guangdong, China

4. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, China

Abstract

A systematic investigation of the flow macrocyclization approaches for five destruxin analogues natural products at three different cyclization point has been reported.

Funder

Harbin Institute of Technology

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01577C

Reference44 articles.

1. Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi

2. The destruxins: synthesis, biosynthesis, biotransformation, and biological activity

3. Development and applications of destruxins: A review

4. Assessing the cytotoxic and mutagenic effects of secondary metabolites produced by several fungal biological control agents with the Ames assay and the VITOTOX® test

5. Synthesis, Structure Determination, and Biological Evaluation of Destruxin E

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