Palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate-Reference-Cited by-同舟云学术

Palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate

Published:2016 Issue:4 Volume:3 Page:466-469
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Feng Zhang¹²³⁴⁵,Xiao Yu-Lan¹²³⁴⁵,Zhang Xingang¹²³⁴⁵

Affiliation:

1. Key Laboratory of Organofluorine Chemistry

2. Shanghai Institute of Organic Chemistry

3. Chinese Academy of Sciences

4. Shanghai 200032

5. China

Abstract

An efficient palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosophonate is described. The method provides a facile access to a series of phosphonyldifluoromethylated alkenes that are of interest in medicinal chemistry. Mechanistic studies reveal that a phosphonyl difluouromethyl radical is involved in the reaction.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/QO/C6QO00005C

Reference26 articles.

1. Catalysis for fluorination and trifluoromethylation

2. Aromatic Trifluoromethylation with Metal Complexes

3. Transition metal catalysis and nucleophilic fluorination

4. Tamed Arene and Heteroarene Trifluoromethylation

5. Recent Advances of Trifluoromethylation

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