A3- and A2B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection-Reference-Cited by-同舟云学术

A3- and A2B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection

Published:2020 Issue:7 Volume:11 Page:771-782
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Bucher Léo¹²³⁴⁵,Kappler-Gratias Sandrine⁶⁷⁸⁵,Desbois Nicolas¹²³⁴⁵^ORCID,Bystricky Kerstin⁹¹⁰¹¹¹²¹³^ORCID,Gallardo Franck⁶⁷⁸⁵,Gros Claude P.¹²³⁴⁵^ORCID

Affiliation:

1. Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB)

2. UMR CNRS 6302

3. Université Bourgogne Franche-Comté

4. 21078 Dijon Cedex

5. France

6. NeoVirTech

7. SAS

8. 31106 Toulouse

9. Centre de Biologie Intégrative (CBI)

10. Laboratoire de Biologie Moléculaire Eucaryote (LBME)

11. University of Toulouse

12. UPS

13. CNRS

Abstract

We report the 2nd generation of seventeen A₂B- and A₃-substituted fluoronitrocorroles and the discovery of optimized compounds with a selectivity index of >200 against hCMV.

Funder

Conseil régional de Bourgogne-Franche-Comté

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00034E

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