Biological evaluation of native streptococcal competence stimulating peptides reveals potential crosstalk between Streptococcus mitis and Streptococcus pneumoniae and a new scaffold for the development of S. pneumoniae quorum sensing modulators

Abstract

Crosstalk between the Streptococcus mitis competence stimulating peptide (CSP) and the Streptococcus pneumoniae competence regulon quorum sensing circuitry was identified.