Protein corona-guided tumor targeting therapy via the surface modulation of low molecular weight PEG

Author:

Cui Teng12345,Ma Yu12345,Yang Jian-Yong67834,Liu Shang91011125,Wang Zhenzhen91011125,Zhang Fenfen12345,Wang Jing12345,Cai Ting12345ORCID,Dong Lei91011125ORCID,Hong Jin13142315,Qian Hai67834,Zhang Can67834ORCID,Ding Ya12345ORCID

Affiliation:

1. Key Laboratory of Drug Quality Control and Pharmacovigilance

2. Ministry of Education

3. China Pharmaceutical University

4. Nanjing 210009

5. China

6. State Key Laboratory of Natural Medicines

7. Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases

8. Center of Drug Discovery

9. State Key Laboratory of Pharmaceutical Biotechnology

10. School of Life Sciences

11. Nanjing University

12. Nanjing 210093

13. Key Laboratory of Biomedical Functional Materials

14. School of Sciences

15. Nanjing 211198

Abstract

Modulating the nature of protein corona on the surface of a nanomedicine via low molecular weight polyethylene glycol provides a new perspective for the regulation of nanomedicine functions such as the protein corona-guided tumor targeted therapy.

Funder

National Natural Science Foundation of China

Double First Class University Plan

Priority Academic Program Development of Jiangsu Higher Education Institutions

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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