ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis-Reference-Cited by-同舟云学术

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ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis

Published:2024 Issue:8 Volume:12 Page:2041-2056
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

McBride David A.¹^ORCID,Wang James S.¹,Johnson Wade T.¹,Bottini Nunzio²,Shah Nisarg J.¹^ORCID

Affiliation:

1. Department of NanoEngineering and Chemical Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA

2. Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

Abstract

The study develops a computational framework to model factors that lead to the evolution of autoreactive T cells in inflammatory arthritis. The results provide a tool for planning immunomodulatory strategies focused on new disease-modifying agents.

Funder

Arthritis National Research Foundation

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM01674A

Reference78 articles.

1. Rheumatoid Arthritis — Common Origins, Divergent Mechanisms

2. The Pathogenesis of Rheumatoid Arthritis

3. Arthritis flares mediated by tissue-resident memory T cells in the joint

4. Identifying the Cells Breaching Self-Tolerance in Autoimmunity

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