Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut

Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut–brain axis

Published:2024 Issue:6 Volume:15 Page:2939-2959
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Xie Yisha¹,Wu Zhengli¹,Qian Qingfan¹,Yang Hao¹,Ma Jieyu¹,Luan Wenxue¹,Shang Siyuan¹,Li Xinli¹²^ORCID

Affiliation:

1. School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, PR China

2. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, PR China

Abstract

C57BL/6 mice were fed with control diet, sugary-diet, or sugary-diet with APE gavage for 8 weeks. After behavioral testing, the samples of serum, hippocampus, colon, and colonic contents were collected for further determination.

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO04606K

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