Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics

Author:

Unterberg Marlies12345,Leffers Larissa123,Hübner Florian623,Humpf Hans-Ulrich12362,Lepikhov Konstantin78910,Walter Jörn78910,Ebert Franziska4511,Schwerdtle Tanja12345

Affiliation:

1. Graduate School of Chemistry

2. WWU Muenster

3. 48149 Muenster, Germany

4. Institute of Nutritional Sciences

5. University of Potsdam

6. Institute of Food Chemistry

7. Department of Genetics/Epigenetics

8. Campus Saarbruecken

9. Saarland University

10. 66123 Saarbruecken, Germany

11. 14558 Nuthetal, Germany

Abstract

This study aims to further mechanistically understand toxic modes of action after chronic arsenic species exposure.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference67 articles.

1. I. P. Pogribny and I.Rusny , in Epigenetic Alterations in Oncogenesis Advances in Experimental Medicine and Biology 754 , ed. A. R. Karpf , Springer , Berlin , 2013 , vol. 754 , pp. 215–232

2. D. Deobagkar , in Toxicology and Epigenetics , ed. S. C. Sahu , Wiley , Chichester, UK , 2012 , pp. 25–50

3. Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer

4. Cancer epigenomics: beyond genomics

5. IARC , IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans, suppl. 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs , Lyon, France , 1987

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