Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach-Reference-Cited by-同舟云学术

Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach

Published:2017 Issue:8 Volume:8 Page:5576-5584
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Aguayo-Ortiz Rodrigo¹²³⁴⁵,Chávez-García Cecilia¹²³⁴⁵,Straub John E.⁶⁷⁸⁹,Dominguez Laura¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Fisicoquímica

2. Facultad de Química

3. Universidad Nacional Autónoma de México

4. Mexico City

5. Mexico

6. Department of Chemistry

7. Boston University

8. Boston

9. USA

Abstract

Employing a multiscale modeling approach, we characterized the structure and dynamics of the γ-secretase complex to elucidate its activation mechanism.

Funder

National Institutes of Health

Consejo Nacional de Ciencia y Tecnología

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00980A

Reference57 articles.

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3. Alzheimer's disease

4. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

5. -Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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