Hyperthermia-induced stellate cell deactivation to enhance dual chemo and pH-responsive photothermal therapy for pancreatic cancers-Reference-Cited by-同舟云学术

Hyperthermia-induced stellate cell deactivation to enhance dual chemo and pH-responsive photothermal therapy for pancreatic cancers

Published:2022 Issue:42 Volume:14 Page:15735-15748
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Hu Qinglian¹^ORCID,Xu Minjie¹,Feng Jiayu¹,Xie Hui²^ORCID,Li Jingyu¹,He Ying¹,Tang Guping³^ORCID,Guo Bing⁴^ORCID

Affiliation:

1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China

2. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China

3. Department of Chemistry, Zhejiang University, Hangzhou 310028, China

4. School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen, 518055, China

Abstract

Lipid nanoparticles loaded with dual gemcitabine and pH-sensitive photothermal drug generate local hyperthermia, assist in deactivating pancreatic stellate cells, enhance drug penetration and significantly boost chemo-phototherapy outcomes.

Funder

Natural Science Foundation of Zhejiang Province

Science, Technology and Innovation Commission of Shenzhen Municipality

Harbin Institute of Technology

Basic and Applied Basic Research Foundation of Guangdong Province

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR04235E

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