Selectivity and stability of N-terminal targeting protein modification chemistries-Reference-Cited by-同舟云学术

Selectivity and stability of N-terminal targeting protein modification chemistries

Published:2023 Issue:1 Volume:4 Page:56-64
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Barber Lydia J.¹²³^ORCID,Yates Nicholas D. J.¹²,Fascione Martin A.¹²^ORCID,Parkin Alison¹^ORCID,Hemsworth Glyn R.⁴^ORCID,Genever Paul G.²³,Spicer Christopher D.¹²³^ORCID

Affiliation:

1. Department of Chemistry, University of York, Heslington, YO10 5DD, UK

2. York Biomedical Research Institute, University of York, Heslington, YO10 5DD, UK

3. Department of Biology, University of York, Heslington, YO10 5DD, UK

4. Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK

Abstract

Protein N-termini provide uniquely reactive motifs for single site protein modification. A comprehensive comparative study of the most promising modification reagents is performed, finding that there is no ‘one size fits all’ approach.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D2CB00203E

Reference23 articles.

1. Advances in Chemical Protein Modification

2. Imaging and manipulating proteins in live cells through covalent labeling

3. Chemical methods for modification of proteins

4. Selective chemical protein modification

5. Designing logical codon reassignment – Expanding the chemistry in biology

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